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For a broader look at common treatment reactions, our guide to GLP-1 side effects in 2026 is a helpful next read

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Prescribing information (Amneal Pharmaceuticals, 2025)

A 2025 review on the effects of weight cycling on muscle and sarcopenia suggested that it may lead to disproportionate fat regain, reduced FFM, accelerated age-related muscle loss and an increased risk for functional impairment and disability, particularly in older or frail individuals, contributing to worsened muscle health outcomes including sarcopenic obesity [14]

Lancet Diabetes Endocrinol 2021;9:825-36.ArticlePubMed 129
