glp 1 gip vs tirzepatide GLP-1 vs. GLP-1 + GIP: What's the Difference for your Metabolism? Frontiers | GLP-1/GIP dual agonist
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Risperidone (0.53 mg/day) also has good evidence but is not clearly better than the approved options

And even if that peptide pill does get approved for weight loss, theres still a ton of interest in developing a small-molecule pill

Researchers compared outcomes among those who received GLP-1RAs vs
Influence of Menopausal Hormone Therapy on Body Composition and Metabolic Parameters
GLP-1R-mediated dopaminergic modulation may vary by drug class: in alcohol models, suppression of dopamine release is coupled with reduced locomotor sensitization [7,24], whereas in psychostimulant paradigms, GLP-1R activation primarily blunts drug-induced dopamine overflow without abolishing baseline dopaminergic tone [10]
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