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those above 5,000 rarely do

Dhindsa S, Prabhakar S, Sethi M, et al

While patients should generally not discontinue tirzepatide without medical guidance due to potential glycemic deterioration, they should immediately stop the medication and seek urgent medical care if they develop symptoms of pancreatitis (severe, persistent abdominal pain, sometimes radiating to the back) or serious allergic reactions

The dual action shows promise for weight control while potentially avoiding a major drawback of current GLP-1 medications: nausea and vomiting

Adults who discontinued their medication within the first 3 months lost 3.6% of body weight at 1 year, whereas those who discontinued pharmacotherapy at 3 months to 1 year achieved a 6.8% weight loss