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When possible, tapering may help manage appetite changes and side effects, although forced interruptions sometimes occur

Fatty acid induction of GLP-1 secretion has been demonstrated in vitro using murine enteroendocrine STC-1 cells [251] and human intestinal NCI-H716 cells [251,253] and in vivo by direct administration of lipids into the duodenum [288,289] or ileum [210]

Poor food choices on tirzepatide produce worse outcomes than on any other weight loss approach because the absolute food quantity is so much lower

ELISA was performed on serum samples from seven patients receiving the active drug

Current preoperative assessment for patients treated with GLP-1 RAs emphasizes individualized evaluation based on the route of administration, duration of therapy, and presence of gastrointestinal symptoms, suggesting that tailored management according to patient-specific risk is more appropriate than a uniform prolongation of fasting periods