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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily prescribed for type 2 diabetes management and, more recently, for weight management in adults with obesity or overweight with weight-related comorbidities

These analogues have attracted the interest of pharmaceutical companies due to their well demonstrated beneficial effects on obesity and diabetes

health agencies have highlighted hundreds of cases of acute pancreatitis, some fatal, in individuals taking semaglutide-based medications such as Ozempic

John Horneff, an associate professor of orthopedic surgery at the University of Pennsylvania and the lead author of the study, told NBC News

Tolerability, safety and pharmacodynamics of oral, small-molecule glucagon-like peptide-1 receptor agonist danuglipron for type 2 diabetes: a 12-week, randomized, placebo-controlled, phase 2 study comparing different dose-escalation schemes