oral glp-1 agonists receptor are generating a great deal of excitement as a potential inflection point in diabetes and obesity care. Amid the enthusiasm, however, a quieter and clinically important issue is GLP-1 Agonists: A Comprehensive Overview

With weight loss, there is also loss of fat-free mass, which raises concern for the development of sarcopenia

Glucose-dependent insulinotropic peptide signaling pathways in endothelial cells

2022;145:e8951032

Data availability The datasets generated and analysed during the current study are not publicly available due to ethical consideration, but are available from the corresponding author on reasonable request

Advances in cryo-electron microscopy imaging of receptor structures, and the ability to create dynamic models to understand how the receptors change shape, are now crucial parts of GPCR drug discovery that allow initial in silico screens