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Arch Dermatol

The definitive study came from X-ray crystallography whereby the isolated ECD of hGLP-1R from an Escherichia coli inclusion body preparation was incubated with the peptide antagonist exendin 939 , before being further purified, crystallized, and analyzed using X-ray diffraction to yield a 2.2 crystal structure (Runge et al., 2008)

These effects are in all likelihood indirect: in the mouse atrium, an increase in beating rate per se reduces FOC, probably of depressed release of Ca 2+ from the sarcoplasmic reticulum (Stemmer and Akera 1986)

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