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Role of Exendin-4 in the Gila Monster: Further Lessons Regarding Human Oral Glucagon-Like Peptide-1 Therapy

GLP-1 receptor agonists also suppress glucagon secretion from pancreatic alpha cells, slow gastric emptying, and promote satiety through central nervous system pathways

Every ingredient was meticulously chosen with purpose and backed by science
Exenatide (Byetta), approved in 2005, was based on exendin-4, a naturally occurring peptide from the Gila monster with inherent DPP-4 resistance

The SURPASS program established efficacy in type 2 diabetes across multiple comparators, including head-to-head superiority versus semaglutide on HbA1c reduction in SURPASS-2 (Fras et al., NEJM, 2021)
