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Also, 77.1% of participants in the semaglutide group achieved weight loss 5% from baseline at week 104, compared to 34.4% in the placebo group

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All three tirzepatide doses were more effective than basal insulin both in reducing HbA 1c (mean differences ranging between 7.66 mmol/mol [0.70%] with tirzepatide 5 mg and 12.02 mmol/mol [1.09%] with tirzepatide 15 mg [ESM Fig

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FIGURE 1 2.1 The GLP-1 pathway influences different alcohol-mediated responses in animals 2.1.1 Alcohol consumption Using two different bottle choice models, alcohol drinking over a prolonged period of time can be monitored in animals ( Similar to the results obtained with acute injection, repeated liraglutide treatment (six injections over 2 weeks) of alcohol-experienced male rats has been shown to decrease both alcohol consumption and preference for alcohol ( Although the aforementioned preclinical studies with GLP-1R reveal a role for the receptor in alcohol drinking, the importance of GLP-1 itself has not been studied as intensely