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The SURMOUNT-1 study was a placebo-controlled 72-week trial in obese subjects that randomized 2,539 participants without diabetes into four equally large study arms with placebo or one of the three tirzepatide doses (5, 10, or 15 mg once weekly)

6 Lead author Khang Duy Ricky Le, MD, senior lecturer in clinical medicine at Deakin School of Medicine, says, It became a passion project to look into the research. Le, et al, determined evidence exists that GLP-1s may improve OSA, as defined by a reduction in the AHI

Oral Contraceptives : Tirzepatide can reduce their effectiveness by up to 55%, increasing pregnancy risks

Rapid Weight Loss Weight loss itself requires metabolic adaptation

regulators first issued warnings in 20072008 regarding severe, sometimes fatal cases tied to Byetta (exenatide)