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Then there's the PBM

Large increases in exercise above an individuals typical weekly level are associated with higher minimum heart rate , suggesting increased physiological strain
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doi: 10.1039/C5FO01101A

Some patients demonstrate primary non-response, where even optimal dosing produces minimal clinical benefit

First, there is significant evidence that PPG neurons are activated by nauseainducing agents, such as LiCl or LPS (Rinaman, 1999a, 1999b)
