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The retrospective design relies on diagnostic coding, which can vary across providers, and factors such as baseline visual acuity and medication adherence were not fully captured
Most clinical studies showing the highest percentages of weight loss were conducted with patients reaching and staying at this level
Vildagliptin appears to have a neutral effect, while saxagliptin has a negative effect on bone, increasing osteoclastic activity and decreasing osteocytic and osteoblastic activity in the femur in preclinical studies [108, 109, 109]
