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Considerations regarding adverse effects and contraindications for different drug classes are provided to help guide treatment decision-making when considering pharmacotherapy for weight management in patients with obesity.

Kidney diseases along with promising but less consistent evidence in liver diseases, while research in autoimmune diseases and dementia remains preliminary.

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Retatrutide is Eli Lillys once weekly injectable that targets three pathways at the same time, GLP-1, GIP, and glucagon