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High-fat dietfed mice treated with exendin-4 displayed decreased mRNA levels of the proinflammatory cytokines monocyte chemoattractant protein 1, tumor necrosis factor- , and signal transducer and activator of transcription 3 (Koehler et al., 2009), and, in a type 1 diabetes animal model in which islets were transplanted into nonobese diabetic mice, GLP-1/gastrin treatment increased the number of transforming growth factor- 1secreting lymphocytes and decreased IFN- secreting lymphocytes with delayed onset of diabetes (Suarez-Pinzon et al., 2008)

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This is a genuine safety issue