weight loss drugs that are not glp 1 GLP-1 for Loss: Every Option Compared Compound versions of GLP-1 drugs

doi: 10.1056/NEJMoa2032183 52 WaddenTABaileyTSBillingsLKDaviesMFriasJPKorolevaAet al

Effect of renal impairment on the pharmacokinetics of the dipeptidyl peptidase-4 inhibitor linagliptin

They switch because external factors force their hand or because specific side effects become intolerable

Studies using functional MRI (fMRI) with food pictures have shown that dietary intake and the consequent increase in endogenous GLP-1 levels reduce the activation of the insula region in diabetic subjects compared to lean subjects [15]

The hedonic value of a food is determined by its palatability (flavour, texture, etc.), the environment in which the food interacts with the subject, and ultimately the homoeostatic and motivational state of the subject