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See our guide on best time of day to take semaglutide Step 5: Rule out medical factors Get thyroid levels checked (TSH, free T3, free T4) Check for insulin resistance markers (fasting insulin, HOMA-IR) Review current medications for weight-promoting side effects Assess for conditions that impair weight loss response When to switch medications or sources Sometimes the best answer is not to fix your current compounded semaglutide but to change course entirely

Example tapering approach (for guidance only): If you are on a higher weekly dose, your clinician may reduce the dose step-by-step over several weeks, such as lowering the dose every 12 weeks (for example, from a higher dose to a mid dose, then to a lower dose) before stopping completely

Although once-monthly dosing would normally mean 12 injections a year, 13 are needed because, to reduce side effects, lower doses are initially given at intervals shorter than one month