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Hydration becomes even more important with these medications because: They slow gastric emptying, potentially worsening dehydration Side effects like nausea improve with proper hydration Consider setting timed reminders or carrying a reusable water bottle throughout the day

While numerous preclinical studies demonstrate robust effects of GLP-1RAs on addiction-related behaviors through modulation of mesolimbic circuits, the assumption of direct CNS penetration has been increasingly questioned

Preclinical proof of concept of enhanced body weight lowering relative to GLP-1 mono-therapy without impaired glycemic control was first demonstrated by two independent research efforts

If you need to adjust by a day or two occasionally, that is fine, but avoid regularly shifting your injection day

As body weight decreases, the dose of levothyroxine needed to maintain euthyroidism may change, typically requiring a reduction in thyroid hormone replacement