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Patients with severe gastroparesis may experience altered drug absorption and increased side effects, potentially affecting the speed of therapeutic response

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From a medical standpoint, that is not the issue

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Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

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72 But the phase 3 Exenatide PD3 trial that followed could not replicate those findings

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