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Not only tirzepatide displayed a 20-fold lower potency in cAMP generation compared with native GLP-1, but also showed a signaling bias towards cAMP instead of beta-arrestin recruitment [39, 42]
The FDA makes exceptions for patients who dont quite meet that threshold but have a related condition, like high blood pressure
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[39] analyzed the uncertain association between glucagon-like peptide-1 receptor agonists and risk of gastrointestinal cancer
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