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El aclaramiento de semaglutida en pacientes con diabetes tipo 2 es de aproximadamente 0.04 L/h

This is what a large-scale meta-analysis in the British Medical Journal shows that gastrointestinal complaints are the main side effect for the entire GLP-1 class, but that the profile varies by drug and dose

However, it is rapidly degraded by the DPP-4 enzyme, giving it a one-two minute half-life