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Furthermore, the trajectory of the weight loss curves suggested that at 48 weeks the plateau of weight was not yet reached and all the participants in the 8 and 12 mg had a weight reduction of 5% or more, which is currently the minimum threshold for efficacy [64]

Although the precise dermatologic mechanism remains under investigation, immune-mediated reactions are biologically plausible

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doi:10.1016/j.physbeh.2008.07.018 231

If you feel unusually cold after starting GLP-1 treatment, comfort measures such as layering clothing, drinking warm fluids and keeping active may help