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10.1007/s00125-008-1195-5 47
1,2 GLP-1 receptors are densely expressed in the hypothalamus and brainstem the same regions that house the orexin neurons responsible for stable wakefulness
Chronic hyperglycemia is a well-known risk factor for cardiovascular disease, and better glycemic control can reduce the risk of atherosclerosis and its complications 20
doi: 10.1111/dom.12824 [DOI] [PubMed] [Google Scholar] 32
Eli Lilly: Tirzepatide/Mounjaro Lily initially developed Tirzepatide as a dual agonist, with a half-life of around 5 days, for the treatment of T2DM
