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A third target is intestinal microbiomes and metabolic endotoxemia
![Figure][1] Graphical Abstract: ### Competing Interest Statement The FR + FMG laboratory receives funding from AstraZeneca, Eli Lilly and LGM for unrelated research and FMG consults for Kallyope (New York)
This was attributed to insulin deficiency and vomiting-induced acid loss and bicarbonate retention
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