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dose adjustments of concomitant medications may be necessary Renal function : Dehydration from gastrointestinal side effects may precipitate acute kidney injury, particularly in patients with pre-existing renal impairment

Journal reference: Corrao S, Pollicino C, Maggio D, Torres A and Argano C (2024) Tirzepatide against obesity and insulin-resistance: pathophysiological aspects and clinical evidence

Vascular, but not luminal, activation of FFAR1 (GPR40) stimulates GLP-1 secretion from isolated perfused rat small intestine
