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Most weight loss medications act on one or two receptor pathways

A 10 mg Mounjaro dose equals a 10 mg Zepbound dose

TGR5 and Its Physiologic Effects Relevant to GLP-1 and Glycogen Metabolism Takeda G protein-coupled receptor 5 (TGR5), a G protein-coupled bile acid receptor, contributes to improved hepatic insulin sensitivity and subsequent energy metabolism and homeostasis [139]

JAMA Intern Med 182 , 513519 (2022)
