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When Zueler injected this preparation into diabetic dogs he encouragingly observed that it significantly reduced the concentration of sugar and ketone, acidic substances produced in the liver resulting from the breakdown of fats, in their urine

It is important to distinguish between dark urine caused by concentration (which appears deep yellow to amber and clears with increased fluid intake) and abnormal pigmentation suggesting pathology (such as tea-coloured urine indicating bilirubin, or red-brown urine suggesting blood or myoglobin)

First, the room temperature windows assume the medication stays below 86 degrees Fahrenheit at all times

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Even experienced patients may develop suboptimal injection habits over time