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Key Take-Home Messages GLP-1 medications have evolved from twice-daily injections for diabetes to versatile, once-weekly (and soon once-daily pill) options that tackle hyperglycemia, weight, and cardiovascular risk simultaneously

Postmarketing surveillance and observational studies have reported cases of pancreatitis in patients receiving GLP-1 receptor agonists, although a causal relationship remains debated and confounded by underlying disease risk factors (Drucker, 2018)

Glucagon-like peptide 1 (GLP-1), for example, is a peptide secreted by the gastrointestinal tract in response to food intake, which leads to the secretion of insulin and inhibition of glucagon release, both of which facilitate glucose homeostasis

Related articles Kim Yun-mi [email protected]

Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus