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GLP-1 medications carry a black box warning for thyroid C-cell tumour risk

Then, the researchers administered exendin-4 via intrathecal injection to the experimental rats and observed a reduction in pain sensitivity, alleviation of neural inflammation, and suppression of inflammatory factors such as IL-1, TNF-, and iNOS

Commonly reported GLP-1 adverse effectsincluding nausea, vomiting, constipation, and abdominal discomfortsubstantially overlap with symptoms of an IBD flare, which may complicate safety monitoring and clinical assessment

Secondly, they often contain stimulant ingredients that can cause psychiatric side effects like heart palpitations and anxiety

This neurochemical rebalancing is often beneficial for mood, which is why some GLP-1 users report improved mental clarity and reduced food-obsession anxiety