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GLP-1R activation improves glucose control via enhanced glucose-stimulated insulin secretion [11,12,13], slowed gastric emptying [13, 14], and decreased plasma glucagon levels [13]

Rapid escalation increases side effect severity, particularly nausea and gastrointestinal distress

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The role of GLP-1 receptor dynamics in timing For those who want to understand the deeper science behind timing flexibility, GLP-1 receptor dynamics provide the explanation