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Clinical trials demonstrated increased incidence of cholelithiasis (gallstones) and cholecystitis with tirzepatide, likely related to rapid weight loss

The meal planning strategies from tirzepatide protocols translate well here, with even greater emphasis on lean protein and complex carbohydrates during the initial weeks

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The FDA has approved Wegovy for weight loss in people with and without diabetes

Three models were constructed: Model 1 (crude model), Model 2 (adjusted for age and sex), and Model 3 (fully adjusted for potential confounders including BMI, blood pressure, lipid profile, renal function, osteocalcin (OCN), vitamin D levels, HbA1c, statin use, antihypertensive medication use, and smoking status)