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Another factor to consider is long-term benefits with weight-loss or possible disease improvement would require continued use of GLP-1 agonist in addition to other IBD treatment options, which can be an additional financial or emotional burden on patients that would need further exploring as well.

While originally developed for blood sugar management, GLP-1 and GIP therapies are now commonly used under medical supervision to support metabolic health, weight management, and body composition in individuals who meet appropriate criteria

The most common side effects in the retatrutide group were gastrointestinal symptoms, which were dose-dependent and mostly mild to moderate in severity

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