glp-1 and gip/glp-1 receptor agonists GLP1-GIP co-agonists: a promising evolution in the treatment of type 2 diabetes | Acta Diabetologica Targeting GLP-1, GIP & GCG

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Is berberine a GLP-1 agonist

Our better understanding of the weight regulation mechanisms and the role of gut-brain axis on appetite has led to the development of safe and effective entero-pancreatic hormone-based treatments for obesity such as glucagon-like peptide-1 (GLP-1) receptor agonists (RA)

Common versions include tirzapetide (Mounjaro/Zepbound), semaglutide (Ozempic/Wegovy/Rybelsus) and are available orally or subcutaneously (injections)

Although rare, associations with nonarteritic anterior ischemic optic neuropathy, pancreatitis, medullary thyroid carcinoma, and acute kidney injury (AKI) have been reported, primarily through pharmacovigilance and case-based evidence