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Gastrointestinal adverse events: The most common adverse effect is gastrointestinal adverse events

Although the direct inhibition of DPP-4 activity does not seem to regulate bone remodeling, the impact of DPP-4 on bone metabolism is indirect, involving the modulation of DPP-4 substrates and inflammation within the bone microenvironment

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According to the PICOS (Population, Intervention, Comparison, Outcome and Study Design) principles, a literature search was conducted in conjunction with the following MeSH and keywords: For population: diabetes mellitus OR diabetes OR diabetic

Here we demonstrate that mice treated with either semaglutide or GLP-1MK-801 exhibit a similar yet transient effect on exercise avoidance (Extended Data Fig