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Consider the risks and benefits of Sitagliptin Tablets prior to initiating treatment in patients at risk for heart failure, such as those with a prior history of heart failure and a history of renal impairment and observe these patients for signs and symptoms of heart failure during therapy
Exposure to excessive heat or freezing temperatures can denature the protein-based medication, rendering it ineffective

Myocardial injury and function: Among the outcome estimates, significant benefits were reported in 4 of 8 for left ventricular ejection fraction (LVEF), 10 of 17 for systolic blood pressure (SBP), 5 of 12 for LDL cholesterol, and 1 of 1 for final infarct size

Williams, E

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