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I 2 = 0%), menstrual regularity, insulin sensitivity, and multiple anthropometric and hormonal parameters (Zhou et al., 2023)

Similar findings are reported for the combination of insulin with DPP-4 inhibitors [909]

Evidence from clinical trials remains sparse, but that is about to change

Clinical trials show that slower titration schedulesstarting at 0.25 mg weekly and increasing by 0.25 mg every 4 weeksreduce nausea incidence by 30-40% compared to faster protocols

Laursen JC, Sondergaard-Heinrich N, Lopes de Melo JM et al (2021) Acute effects of dapagliflozin on renal oxygenation and perfusion in type 1 diabetes with albuminuria: a randomised, double-blind, placebo-controlled crossover trial