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Areas like the cheeks, temples, under-eyes, and jawline can lose volume, leading to a hollowed or sagging appearance
La semaglutida se debe utilizar con precaucin en pacientes en tratamiento con medicamentos orales que requieren una absorcin gastrointestinal rpida

The mechanism of this is unknown but poor penetration of peripheral leptin to hypothalamic regions due to reduced capillary transport system in hypothalamic microcirculation could be responsible for its limited efficacy as an anti-obesity drug (47)
