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One thing to keep in mind here: Some compounded formulations use semaglutide salts (such as semaglutide sodium or acetate) instead of the semaglutide base found in the name brand medication, which may affect their safety and effectiveness

Blinding in the STEP 1 to STEP 4 trials may have been compromised somewhat, however, by the fact that the primary outcome is based on a readily measurable, objective measure (weight loss) that patients can self-monitor, and by the large imbalance in GI AEs, a well-known complication of GLP-1 agonists

When it comes to helping clients make informed decisions about proceeding with GLP-1 treatment, Kimberly recommends choosing a provider that takes a hands-on approach, one that doesnt just send patients home and wish them good luck

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A comprehensive assessment of frailty, hydration status, polypharmacy, and risk of malnutrition is advisable before initiating treatment in older adults