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As obesity is known to increase the risk of cardiovascular disease, including HF, therefore, anti-obesity interventions like tirzepatide may have cardioprotective effects [101]

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These results indicate tirzepatide produced meaningful benefits for people living with heart failure with preserved ejection fraction [HFpEF] and obesity, said lead study author Milton Packer, M.D., a distinguished scholar in cardiovascular science at Baylor University Medical Center in Dallas and a visiting professor at Imperial College in London