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Approximately 57% of patients experienced decrease in appetite, which was consistent across the PIONEER trials [35,36,37,38,39,40,41,42,43,44]

[DOI] [PubMed] [Google Scholar] 128.Natale P., Palmer S.C., Navaneethan S.D., Craig J.C., Strippoli G.F

Additionally, GLP-1 has indirect glucagonostatic effects that may assist in counteracting hyperglucagonaemia in T2DM [16,17], which may be mediated through upregulation of somatostatin secretion via somatostatin-2-receptor (SSTR2) [17]

Julius A, Hopper W

Clinical trials for these treatments have consistently highlighted digestion challenges as the most prevalent side effects clinical studies for Wegovy PI, for example, showed 44% of patients suffered nausea (compared to 16% in the placebo group)