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However, no direct head-to-head comparisons have been conducted, and the 48-week timeframe in the retatrutide trial is shorter than the 6872 week endpoints used in the semaglutide and tirzepatide phase 3 trials, making direct numerical comparison imprecise

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In SURMOUNT-OSA 1, which included patients who were not using PAP therapy, 43% of participants on the highest dose met the criteria for disease resolution

Keep in mind that microdosing does not make the medication less effective