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P values lower than 0.05 were considered significant

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This finding may contribute in part to the explanation for why the combination of agonists targeting both the GIP and GLP-1 systems has yielded promising results in preclinical models and clinical trials, providing greater body weight loss and better glycemic control than GLP-1R agonism alone (25,5457)

The treatment algorithm recommended by ADA and EASD is summarized in Figure 3 (72, 73)
