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The combination is not FDA-approved and lacks sufficient clinical research on safety and efficacy

Katherine Saunders, MD , is an obesity medicine physician, clinical assistant professor of medicine at Weill Cornell Medicine, and co-founder of Intellihealth

The news came as a huge disappointment to the research community

Therefore, pharmacological activation of ERRs may provide beneficial metabolic effects associated with increased skeletal muscle activity for the treatment of metabolic diseases

However, further metabolomic and proteomic studies are still needed to investigate the mechanisms of relevant microbial metabolism-host interactions