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GLP-1/GIP weight loss program also triggers the release of more adiponectin , a hormone that fights against inflammation, enhances insulin sensitivity, and helps prevent the onset of diabetes and cardiovascular disease

Pancreatic islet alpha cells release factors, like glucagon, that stimulate beta cell function and increase glucose-dependent insulin secretion [76]

The main incretin hormones secreted by the epithelial cells of the gastrointestinal track are glucagon-like peptide-1 (GLP)-1 and glucose-dependent insulinotropic peptide, also known as Gastric Inhibitory Polypeptide (GIP), which stimulate the pancreatic cells ( and cells) and regulate insulin secretion with respect to blood glucose concentration (Drucker, 2006)

Once-weekly administered tirzepatide proved to be both noninferior and superior in reducing glycosylated hemoglobin levels in T2DM patients and demonstrated robust weight loss in obese patients [27,28]

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