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As for mortality, both SGLT-2 inhibitors and GLP-1RA are similar in reducing both total and CV deaths, but SGLT-2 inhibitors only are superior to DPP-4 inhibitors for both deaths, whereas GLP-1RA are superior to DPP-4 inhibitors for total death, but equal for CV death
One study estimated the economic burden of MS in the United States to be $85 billion in 2019, projected to increase to $108 billion by 2039 [7]

Furthermore, DKD is an established risk factor for cardiovascular disease (CVD) (Rawshani et al., 2018)

doi:10.1007/s11906-008-0044-8 88

Research involving GLP-1R KO mouse models and in vitro bone cell studies indicated that GLP-1Ra could be advantageous for bone health, even when weight loss is pharmacologically induced
