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Checklist: Common Side Effects Nausea Vomiting Diarrhea Constipation Abdominal pain Fatigue Increased heart rate or palpitations Mild liver enzyme changes (ALT/AST elevations) Injection-site redness, itching, or nodules Common Reactions Nausea, constipation, and fatigue are the most common

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Among the possible downsides of taking tirzepatide or semaglutide: an increased risk of thyroid tumors, GI symptoms, and gallstones

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