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Collectively, in wild-type and mig-6L(qz2) mutants, across two Notch activation assays ( GLP-1(NICD)::GFP and SALSA) as well as the PZ size readout, our data strongly support a positive relationship between DTC-AC levels and GSC GLP-1/Notch receptor activation

However, the oncological significance of GCG signaling remains insufficiently defined, and the currently available evidence does not support a uniform conclusion that GCGR activation exerts a direct antitumor effect (61)

Strengths and Limitations Strengths : The report provides a novel indication for tirzepatide that extends beyond glycemic control into dermatological applications

[15] The lesson: Slow and steady wins the race (or at least ties, albeit with far less nausea)

Effects on substance use