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Semaglutide also showed a 20% reduction in MACE in overweight or obese adults with preexisting ASCVD but without diabetes, according to the Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity (SELECT) trial [7,8]

Endogenously, GLP-1 is secreted by intestinal L cells in response to food, and has multiple roles: enhancing insulin secretion (in a glucose-dependent way), reducing glucagon secretion, slowing gastric emptying, increasing feelings of fullness/satiety, and improving glucose disposal in peripheral tissues
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