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Preparation To prepare for a semaglutide or tirzepatide treatment you will need to: Stop drinking alcohol 24 hours before and after the treatment because alcohol affects your blood sugar levels Make arrangements to eat a healthy, balanced diet Set aside time for regular exercise Schedule your weekly treatments at a convenient time to help you stay on track You will need to be mentally prepared to make changes to your daily routine and lifestyle to help you stay consistent with eating healthy and exercising regularly