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Naturally occurring mutations in G protein-coupled receptors associated with obesity and type 2 diabetes mellitus

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As of October 2024, a handful of these products are in late-phase clinical trials, with active ingredients such as retatrutide, survodutide and ecnoglutide, and more than 18 other drug candidates are in earlier stages of development

This shift towards oral medications is expected to make effective weight loss treatments available to a broader population

Authors contributions X-L and Z-H contributed to the study concept and design and revised the draft