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Consistent with these actions, anamorelin, a GHSR agonist, improves appetite and increases muscle specific mass in patients with cancer cachexia [153,154,155]

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However, in another study, colesevelam alone or co-administered with CDCA does not have an acute effect on GLP-1 secretion in humans with or without diabetes [179]

Note: These dosing guidelines are from clinical trials only and not yet FDA approved